$380,000 buys the median home in Salem right now. With 20% down, that's a $76,000 down payment and a $304,000 loan, set against a $60,000 median household income.
Salem's 0.94% property tax rate runs below the 1.1% national average. That's $298/month on the median home here, not a rounding error against the mortgage payment.
Oregon levies a state income tax on top of the $2,426/month this mortgage runs. Model your real after-tax take-home before deciding how much payment you can carry.
Salem's cost of living index is 100, at the 100 national baseline. That's on top of the housing numbers above, not instead of them.
Salem's median home price runs 25% lower than nearby Portland: $510,000 there versus $380,000 here.