Home prices in Palo Alto run 662% above the national median: $3,200,000 versus $420,000. Relative to the $550,000 median household income here, the price-to-income ratio comes out to 5.8x.
At a 0.73% effective rate, Palo Alto property taxes add $1,947 to the monthly payment on the median home, $23,360 a year in total.
California levies a state income tax on top of the $19,788/month this mortgage runs. Model your real after-tax take-home before deciding how much payment you can carry.
Palo Alto's cost of living index is 228, above the 100 national baseline. That's on top of the housing numbers above, not instead of them.
Palo Alto's median home price runs 258% higher than nearby Los Angeles: $895,000 there versus $3,200,000 here.